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At Memorial Sloan Kettering (MSK), we're not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we're driving excellence and improving outcomes. We're treating cancer, one patient at a time. Join us and make a difference every day.

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Job Description

Postdoctoral positions in single particle cryo-EM of biomacromolecular complexes

Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

The Dinshaw J. Patel laboratory in the Structural Biology Program at the Memorial Sloan-Kettering Cancer Center (MSKCC) has openings for several postdoctoral positions for individuals with biochemical and single particle cryo-EM training and experience in biomacromolecular structure determination.

Preferred qualifications include a PhD in structural biology with biochemistry training working with soluble/membrane proteins and/or RNA, hands-on experience with single particle cryo-EM sample preparation and optimization, data collection and processing, coupled together with strong organizational and communication skills. We are interested in self-motivated candidates who exhibit qualities reflective of independent thinkers and conceptual contributors, who are capable of working both independently and as part of a team effort.

Research in the Patel lab is focused on the following areas: (1) Mechanistic insights into CRISPR-Cas and cGAS-STING surveillance complexes and suppressors of these pathways; (2) Structure and regulation of DNA-bound Structural Maintenance of Chromosomes (SMC) Smc5/6 and Mre11/Rad50 complexes, as well as multi-subunit complexes associated with double strand break (DSB) repair in meiosis; (3) Role of histone and DNA posttranslational modifications in epigenetic regulation; (4) Structure and catalytic mechanisms of nucleolytic ribozymes and small RNA silencing pathways; (5) Structure-guided optimization of small molecules targeted to viral pathogenic proteins and protein-RNA complexes, towards collaborative efforts at accelerated development of therapeutic agents.

MSKCC, which is located across the street from Rockefeller University and Weill-Cornell Medical School, offers ample opportunities for collaborative research within the tri-institutional campus location. Highlights of recent research contributions from the Patel lab can be found on Dinshaw J. Patel's MSKCC web site under 'View Lab Overview', together with a detailed outline of accomplishments listed under 'Research Projects'. The web site also lists prominent publications from the Patel lab spanning the 2019 - 2022 time frame.

The Patel lab has access to state-of-the-art cryo-EM facilities both in-house at MSKCC (one operational Titan KRIOS instrument and another on order), on a time-share access at the New York Structural Biology Center [NYSBC] (four operational KRIOS instruments) and on BAG time access at the National cryo-EM Facility [NCCAT] at NYSBC (four operational KRIOS instruments).

MSKCC provides competitive salaries and fringe benefits, access to subsidized institutional housing, and secures long-term H1-B visas. This is an annual appointment renewable by mutual agreement, with motivated postdoctorals staying up to 5 years of training, thereby providing them with sufficient time to be productive and meet their career goals.

Interested candidates should contact Dr. Dinshaw J. Patel by email (pateld@mskcc.org) with an updated cv and a cover letter containing a research statement, as well as contact information for 3 references.

Qualification

PhD

Job Type

Postdoctoral

Discipline

Structural Biology

Hours

Full-time

Duration

Fixed term. Annual appointment renewable by mutual agreement for up to 5 years

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