Research Fellow- Computational Systems Immunology - Miraldi Lab
Cincinnati Children's Hospital Medical Center
Location: Cincinnati, Ohio
Academic / Research
Internal Number: 116939
POSITION TITLE: RESEARCH FELLOW-Data/Technology
SUPERVISOR'S TITLE: Faculty
TITLES SUPERVISED: Research Assistants; Data Analysts; Biostatisticians
TOTAL NUMBER OF FTE's DIRECTLY OR INDIRECTLY SUPERVISED: 0-4
PURPOSE OF POSITION: Dr. Miraldi's Immuno-Engineering Laboratory seeks a computational research fellow to build mathematical models of the immune system in vivo. These models will be constructed from cutting-edge, high-dimensional, immune-system measurements (e.g., single-cell genomics, chromatin state, proteomics). Our mathematical modeling frameworks span mechanistic (e.g., dynamic gene regulatory networks) to deep learning (e.g., prediction of cellular epigenomes from DNA sequence). Situated at Cincinnati Children's Hospital, we are dedicated to the design of computational methods and systems-immunology studies that will ultimately improve the health of children. Through close collaboration with our physician and experimental colleagues, we iteratively test and refine our models, so that the models yield novel insights into immune-cell function and ultimately guide new therapeutic strategies in the context of autoimmunity, infectious disease and cancer. The ideal candidate will collaborate closely with experimental immunologists, physicians and other computational biologists. The team will design and execute hybrid computational-experimental strategies that push the boundaries of both immunology and computational biology.
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER
Cincinnati Children's Hospital Medical Center is a premier pediatric research institution with over 900 diverse and productive faculty members. Here, researchers work collaboratively across specialties and divisions to address some of the biggest challenges we face today in improving child health. A strong network of research support services and facilities, along with institutional commitment to research, push our team of faculty, postdocs and support staff to explore the boundaries of what is possible, leading to significant breakthroughs. We are driven by our mission to improve child health and transform the delivery of care through fully integrated, globally recognized research, education and innovation.
???Perform analysis and experiments Design, execute, and record analysis and experiments; apply standard scientific protocols to research, and improve current methods and evaluate innovative techniques. Develop and implement human subject research protocols, vertebrate animal research protocols and design experimental procedures and documentation in accordance with the relevant laws and regulations. Prepare, clean and analyze data. Maintain optimal protocol and accuracy by conducting regular quality and reproducibility checks.
???Communicate results/findings Draft, write, and edit scientific reports, papers, journal articles, and abstracts. Present information on research and department work to others at department meetings, journal clubs, and seminars. Present results and discuss relevant insights with Faculty and provide useful recommendations and analysis.
???Innovate and advance departmental capabilities Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current analysis/experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all analysis and experiments. Develop, set-up, and verify new procedures in the department. Standardize and establish new published procedures; evaluate innovative techniques. Develop new protocols; design formats. Maintain an integral role in the department's meetings, presentations, and publications. Troubleshoot and correct erroneous results or problems with department software/equipment. Maintain and repair software/equipment; monitor proper use by personnel.
???Staff Leadership May provide day-to-day functional leadership for a team or directly manage a minimal number of support staff. Establishes team goals. Gives input into, and performs employee performance reviews. Oversees and guides work assignments. Serves as the functional expert and provides guidance to the team.
???Education and Training May serve as course master and develop new courses at the undergraduate and graduate level, including appropriate plans for evaluating student performance; may deliver lectures as a guest lecturer in courses organized by other faculty. Assist in the training of new employees. Serve as a resource and/or mentor to coworkers. Assist in the development and presentation of department training. Identify training needs and provide necessary coaching.
???Ph.D. in related discipline, MD, or equivalent degree
Preferred: The ideal candidate will have a quantitative background in computational/systems biology, engineering, computer science, statistics, math, or a related field. He or she will also (1) be a fluent programmer in at least one language (e.g., Python, R, MATLAB) and be willing to develop fluency in other languages, as needed, (2) have research experience in machine learning, bioinformatics and/or mathematical modeling, and (3) a trackable publication record. An enthusiasm and willingness to develop immunology expertise on the job is also necessary.
???Programming - Basic Working knowledge of computer programming
???Organization Strong organizational and project management skills to handle projects independently.
???Time Management Prioritization and time-management skills sufficient to meet deadlines in a fast-paced environment
???Analysis Strong analytical skills with the ability to make judgments and recommendations based on statistical analysis
???Statistics - Intermediate Familiarity with statistical software, statistical techniques, statistical process control principles, and graphical data display
???Research Methods Skills Designing and conducting effective research studies that address measurement, data collection, and validity issues; identifying or developing appropriate, accurate, relevant, and reliable measurement methods; drawing appropriate conclusions from study results
???Communication - Advanced Excellent verbal, written and interpersonal communication skills.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.