Summary of Essential Job Duties:

The applicant will assist in the biological and biochemical analysis of the renin-angiotensin system. Work will focus on the immunologic, biochemical and metabolic effects of angiotensin converting enzyme (ACE) on myeloid cells. Several studies from our group has shown that ACE over expression in myeloid cells markedly enhances the function of macrophages and neutrophils (reviewed in Angiotensin-converting enzyme in innate and adaptive immunity. Bernstein KE, Khan Z, Giani JF, et al. Nat Rev Nephrol. 2018 May;14(5):325-336). Our group has recently received an NIH grant to study the mechanism by which ACE causes this effect. We will be pursuing a number of independent avenues, including the effects of ACE on the metabolism of cells. The applicant will be expected to do:

1. Planning, designing, and executing experiments. Includes data interpretation and analysis, and troubleshooting in areas of molecular biology, recombinant techniques, biochemistry, cell culture, RNAi, in vivo techniques, microscopy and molecular imaging. May develop, adapt, and implement new research techniques and protocols.

2. Regular meetings with PI to discuss experimental plans and results.

3. Attendance and participation at regularly scheduled lab meetings and conferences.

4. Presentation and dissemination of research through oral presentations at internal and external meetings, and writing original research articles for publication in scientific journals.

5. Applies for appropriate and eligible fellowship funding and contribution toward acquisition of lab funding for gene and drug delivery research.

6. Participation in training of junior lab members.

7. Contribution to general lab maintenance.

8. Upkeep of well-organized lab book.

9. May assist in preparation of grant proposals, but is not responsible for generating grant funds.

10. May participate in publications and presentations as author or co-author.

11. Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.

12. Analyzes, interprets, summarizes and compiles data.

13. Performs routine and complex laboratory procedures throughout training period.

14. Operates and maintains equipment and instruments

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