Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
POSTDOCTORAL RESEARCH FELLOW - HIGH CONTENT IMAGING
West Point, PA Job # POS000249
Be a part of the legacy: MRL Postdoctoral Research Fellow Program
The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
As a postdoctoral fellow in the Department of Safety and Exploratory Pharmacology you will work with a highly collaborative team of scientists from multiple Departments to develop a novel, systematic multi-parametric in vitro approach for early prediction of drug-induced cardiac adverse events in humans.
Responsibilities include but are not limited to:
- Collecting, critically analyzing and interpreting in vitro safety pharmacology data; - Developing, optimizing, and troubleshooting functional in vitro assays such as high content fluorescent imaging and plate-based electrophysiology; - Handling human induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) and developing and optimizing their culturing conditions; - Acquiring data, performing complex analyses of large data sets, interpreting the results; - In collaboration with modeling experts, developing and optimizing a computational model for prediction of clinical cardiac side effects of drugs, based on their in vitro effects and physico-chemical properties.
Education Minimum Requirement:
- PhD with less than 3 years of Postdoctoral Experience or achieved a PhD by Spring/Summer of 2018
Required Experience and Skills:
- high content multi-channel imaging (HCI) - phenotypic in vitro assay development and validation, - multi-parametric computational image analysis, - visualization of large data sets (Spotfire, etc.) - maintenance and culture of recombinant mammalian cell lines, hiPSC-CMs, and 3D culture - Ability to independently design experiments, interpret and track results, and utilize this information to enable assay development - Understanding of basic principles of cellular pharmacology and physiology - Ability to work effectively and with minimal supervision in a multi-disciplinary team environment, and have excellent organizational and communication skills with a well-developed ability to multi-task and make critical decisions.
Preferred Experience and Skills:
- Experience in data-mining, machine learning, statistical modeling and visual analytics - Working knowledge of signal processing, clustering, and multidimensional data scaling algorithms applied to biological systems - Development and validation of predictive computational models - Strong publication record in peer-reviewed journals - Working knowledge of cellular electrophysiology (chip-based and plate-based).
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To be considered for this position, please visit our career site at merck.com/careers, search jobs, create a profile and submit your resume for requisition #POS000249 to:
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About Merck Sharpe & Dohme Corp
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.